standardized OPC extract of French Maritime Pinebark clinically useful in asthma management

A clinical trial done at the Chieti-Pescara University in Pescara Italy, published in the Sept 2011 issue of Panminerva Medica, showed that a surprisingly small amount of a standardized oliogmeric proanthocyanidin (OPC) extract of French Maritime Pinebark (Pycnogenol®, produced by Horphag Research), made a very significant difference to a group of chronic asthma sufferers, who were already being treated with inhaled corticosteroids. You can read the abstract here. One group received only 50 mg of the OPC concentrate twice daily, while continuing their inhaled corticosteroids, whereas the control group continued to receive only inhaled corticosteroids. It has previously been shown that OPCs decrease expression of an enzyme that produces highly inflammatory fatty acids called leukotrienes, which are known to mediate bronchial muscle inflammation in asthma. Over the 6 month period of the study, nearly 20% of the control group required an increase in the dose of inhaled steroids to keep their asthma under control, whereas none of the Pycnogenol group did. In fact, in the group taking the OPC supplement, 55% of them improved enough that they were able to lower their dose of inhaled steroids, vs only 6% of the control group that was able to lower their inhaled steroid dose.

To quote detailed results from the study: “The levels of asthma control in the 6 interventional months as compared to the same period in the previous year were compared. In the Pycnogenol® group, night-awakenings were less frequent, the number of days with PEF<80% were decreased, days with asthma score >1 were lower, requirement for salbutamol and additional asthma medication less frequent, and consultation of general practitioner and specialist required less commonly. All these parameters were statistical significantly improved in Pycnogenol® + ICS (inhaled corticosteroid) group versus the ICS control group where no considerable changes were observed. Various common signs and symptoms were evaluated by visual analog scale, (dry) cough, severity of chest symptoms, wheezing, dyspnea and daytime symptoms. In the ICS-only group values did not improve while they did improve significantly in the ICS + Pycnogenol® group (P<0.05 vs. ICS only group). A decrease by 15.2% of the specific IgE titer was found in the Pycnogenol® + ICS group, whereas the titer increased by 13.4% in the ICS-only group.”

All that means that the group that received 50 mg of OPC from pine bark supplement twice daily for 6 months experienced very significant clinical improvement in their asthma symptoms, and were able to decrease dependence on medication. That fact that the results were statistically significant with only 76 patients in the whole study indicate that this was a very large effect. Many clinical trials require thousands of patients to demonstrate a statistically significant improvement.

Having grown up with pretty severe asthma myself (I recall one of my professors in medical school telling me that I could expect to develop chronic obstructive pulmonary disease (COPD, also known as emphysema), by the time I would be 60, which I am now well past)– I’ve learned that many nutritional factors can help to heal asthma. In addition to OPCs,  Fish oil (and keeping dietary intake of omega-6 fatty acids low), Evening Primrose oil (or other source of gamma-linolenic acid, an omega-6 fatty acid that is actually anti-inflammatory) vitamin D (5000 IU per day), lipid extract of New Zealand Green lipped mussel,  recognition of food sensitivities (and avoiding those foods) all have helped to the point, that, except for several weeks after the occasional viral upper respiratory infection, I can exercise, even in cold air, without wheezing, be around cats without the asthma attacks that only 25 years ago were predictable after exposure to cats, and generally live an active and for the most part asthma free life. So the only surprise to me about this study, was how little Pine Bark OPC it took to make a very significant clinical difference in this group of people with moderately severe asthma. Personally I have experienced and also seen similar effects in other people with asthma, from supplementation with grape seed derived OPC, and with combinations of grape seed and pine bark OPC concentrates. The important thing is that they be high quality, high purity concentrates, as is the case with Pycnogenol®.

I’m also glad that my medical school professor (who was a specialist in pulmonology, ie study of lung diseases) turned out to be quite wrong about me!

Grape seed extract kills leukemia cells

A new study from the University of Kentucky (where I graduated from medical school in 1975!) was published Jan 1st 2009 in Clinical Cancer Research.

An extract from grape seeds forces laboratory leukemia cells to commit cell suicide, according to researchers from the University of Kentucky. They found that within 24 hours, 76 percent of leukemia cells had died after being exposed to the extract.

This one is particularly dear to my heart, as I have seen (and experienced) first hand the amazing results of supplementation with high quality grape seed (and pine bark) proanthocyanodins (OPCs). One of the frequent comments/questions I receive is “I heard that OPCs were bad to take if you have leukemia or a high white blood cell count”. My answer has always been that I know of no reason for this. Now we have strong evidence,  even including the molecular mechanism (see full article) for the first time, to the contrary